In vivo pharmacology efficacy studies provide critical "proof of concept" for advancing an NCE. At present, ERF has the requisite expertise to deliver on the following efficacy models across therapeutic areas.
Pain and Inflammatory Models
FA/Carrageenan induced hyperalgesia in rats
Carrageenan and LPS induced paw edema in rats
Acetic acid induced writhing in mice
Oxazolone induced ear edema in mice
Neuropathic Pain Models
PSNL induced neuropathic pain in rats
Diabetic Neuropathic Pain (DNP) in rats
STZ induced Type-I diabetes in SD rats
HFD/STZ (low dose) induced Type II diabetes in SD rats (Under Validation)
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